Does paternal age affect the likelihood of success in MAP?

Who I am
Catherine Le Nevez
Author and references

Fonte: shutterstock

Paternal age and MAP

L'paternal age affects the outcome of medically assisted procreation treatments. This is confirmed by a recent study conducted by Dr. Marco Vitali - with the coordination of the doctor Mariabeatrice Dal Cantoe of Dr. José Buratini of the Center of Medicine of Biogenesis Reproduction of the Zucchi Clinical Institutes of Monza, of the San Donato Group, as part of the Master in Assisted Reproduction Technologies of the Pompeu Fabra University of Barcelona.

What effect does age have on sperm quality?

There is no doubt that also for the man, as well as for the woman, the'age plays an important role in fertility and in the chances of success for couples seeking a child and turning to medically assisted procreation centers. With advancing age, sperm volume and motility decrease, while sperm DNA fragmentation increases.

Ma how important is the age of the father in the success of a treatment for MAP?

The research conducted in collaboration with the University of Barcelona took into consideration age, lifestyles and sperm quality and above all related the age of the father to that of the mother.

As explained by Dr. Mariabeatrice Dal Canto: "The study was based on data from 5.565 male patients of the Center for Reproductive Medicine Biogenesis - collected from 2022 to 2022 - divided into five groups based on age - group A (from 25 years to 34 years), group B (from 35 years to 39 years), group C (from 40 years to 44 years) and group D (more than 45 years) - and considered three parameters of semen quality: ejaculate volume, sperm concentration and progressive motility. "

L'effect of paternal age it was also evaluated on healthy patients with a favorable lifestyle, so no smoking, drugs and alcohol intake.

The researchers were thus able to analyze how the paternal age can affect the seed quality, but also how a favorable lifestyle and the absence of pathologies are associated with a higher quality of seminal fluid: volume, concentration, number and motility are, in fact, associated with favorable health conditions and lifestyle.

In both populations, we observed a significant reduction in motility and ejaculation volume with advancing paternal age and we did not find any significant reduction in sperm concentration.

Read also: Infertility, male causes

The impact of male age in relation to maternal age

To evaluate the effect of paternal age on the outcomes of MAP treatments we examined 1.958 cycles with fresh transfer occurred between 2022 and 2022, which presented causes of unexplained infertility, linked to male factor, tubal factor, ovulatory factor, polycystic ovary (PCO) or polycystic ovary syndrome (PCOS) .

The study groups were divided according to age: under 37 and over 37.

The conclusive results suggested that implantation and live birth rates were significantly influenced by paternal age only in couples in whom high paternal and maternal ages are associated.

"We can therefore conclude that the current data suggest a negative incidence of paternal age on parameters related to sperm quality and demonstrate a relevant influence on the outcomes of ART treatments, only if an advanced maternal age is also present at the same time."

  • medically assisted procreation techniques
  • infertility
add a comment of Does paternal age affect the likelihood of success in MAP?
Comment sent successfully! We will review it in the next few hours.